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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
POLE2
All Species:
40.91
Human Site:
Y465
Identified Species:
60
UniProt:
P56282
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P56282
NP_002683.2
527
59537
Y465
V
C
P
V
Y
W
A
Y
D
Y
A
L
R
V
Y
Chimpanzee
Pan troglodytes
XP_509931
527
59578
Y465
V
C
P
V
Y
W
A
Y
D
Y
A
L
R
V
Y
Rhesus Macaque
Macaca mulatta
XP_001095940
525
59213
V464
L
P
L
Y
V
C
P
V
Y
W
A
Y
D
Y
A
Dog
Lupus familis
XP_851216
527
59504
Y465
V
S
P
V
Y
W
A
Y
D
Y
A
L
R
V
Y
Cat
Felis silvestris
Mouse
Mus musculus
O54956
527
59368
Y465
V
C
P
V
H
W
A
Y
D
Y
T
L
R
V
Y
Rat
Rattus norvegicus
XP_216727
527
59187
Y465
V
S
P
V
Y
W
A
Y
D
Y
T
L
R
V
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515002
535
60459
Y473
V
S
P
V
Y
W
A
Y
D
Y
T
M
R
V
Y
Chicken
Gallus gallus
Q5ZKQ6
527
59609
Y465
V
S
P
V
Y
W
A
Y
D
Y
A
L
R
V
Y
Frog
Xenopus laevis
NP_001083783
527
59670
Y465
V
S
P
V
Y
W
A
Y
D
Y
A
L
R
L
Y
Zebra Danio
Brachydanio rerio
NP_775353
527
59243
Y465
V
C
P
V
F
W
A
Y
D
H
T
L
R
L
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_647995
525
58740
Y461
A
M
P
V
H
W
D
Y
D
P
A
L
W
L
Y
Honey Bee
Apis mellifera
XP_001120791
454
52119
Q393
W
K
Y
N
H
S
L
Q
I
Y
P
T
P
D
L
Nematode Worm
Caenorhab. elegans
Q19196
534
60979
F452
I
T
P
V
L
P
D
F
S
H
S
L
S
L
H
Sea Urchin
Strong. purpuratus
XP_796825
501
56117
Y437
V
C
P
V
Y
W
A
Y
D
N
A
L
R
I
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001147081
533
59891
N472
T
V
Q
P
I
I
W
N
Y
D
H
C
L
R
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P24482
689
78322
L626
L
R
P
I
S
W
D
L
D
H
T
L
T
L
C
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
92.4
93.5
N.A.
90.1
90.8
N.A.
86.1
82.1
81
73.2
N.A.
42.1
39.2
30.8
57.6
Protein Similarity:
100
99.2
94.3
97.1
N.A.
94.8
95.2
N.A.
90.8
91.4
91
88
N.A.
59.7
58
51.1
75.7
P-Site Identity:
100
100
6.6
93.3
N.A.
86.6
86.6
N.A.
80
93.3
86.6
73.3
N.A.
53.3
6.6
20
86.6
P-Site Similarity:
100
100
20
93.3
N.A.
93.3
86.6
N.A.
86.6
93.3
93.3
93.3
N.A.
66.6
13.3
60
93.3
Percent
Protein Identity:
N.A.
36.2
N.A.
N.A.
24.3
N.A.
Protein Similarity:
N.A.
56.2
N.A.
N.A.
42.9
N.A.
P-Site Identity:
N.A.
0
N.A.
N.A.
26.6
N.A.
P-Site Similarity:
N.A.
0
N.A.
N.A.
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
0
0
63
0
0
0
50
0
0
0
7
% A
% Cys:
0
32
0
0
0
7
0
0
0
0
0
7
0
0
7
% C
% Asp:
0
0
0
0
0
0
19
0
75
7
0
0
7
7
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
7
0
0
7
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
19
0
0
0
0
19
7
0
0
0
7
% H
% Ile:
7
0
0
7
7
7
0
0
7
0
0
0
0
7
0
% I
% Lys:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
13
0
7
0
7
0
7
7
0
0
0
75
7
32
13
% L
% Met:
0
7
0
0
0
0
0
0
0
0
0
7
0
0
0
% M
% Asn:
0
0
0
7
0
0
0
7
0
7
0
0
0
0
0
% N
% Pro:
0
7
82
7
0
7
7
0
0
7
7
0
7
0
0
% P
% Gln:
0
0
7
0
0
0
0
7
0
0
0
0
0
0
0
% Q
% Arg:
0
7
0
0
0
0
0
0
0
0
0
0
63
7
0
% R
% Ser:
0
32
0
0
7
7
0
0
7
0
7
0
7
0
0
% S
% Thr:
7
7
0
0
0
0
0
0
0
0
32
7
7
0
0
% T
% Val:
63
7
0
75
7
0
0
7
0
0
0
0
0
44
0
% V
% Trp:
7
0
0
0
0
75
7
0
0
7
0
0
7
0
0
% W
% Tyr:
0
0
7
7
50
0
0
69
13
57
0
7
0
7
69
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _